Biological activities of suilysin: role in Streptococcus suis pathogenesis. USA.gov. 2005 Oct;110(4):369-82. doi: 10.1007/s00401-005-1055-z. Streptococcus (S.) suis is an invasive porcine pathogen causing meningitis, septicemia, arthritis and other diseases. eCollection 2015. G. Trautwein. Phase-dependent expression of matrix metalloproteinases and their inhibitors in demyelinating canine distemper encephalitis. Heredity (Edinb). Canine distemper virus (CDV) belongs to the genus Morbillivirus of the Paramyxoviridae family. eCollection 2019 Dec 10. Epub 2017 Nov 28. Clinical manifestations related to meningitis, arthritis and serositis could be induced by intravenous application of this serotype 9 strain. Alldinger S, Fonfara S, Kremmer E, Baumgärtner W. Acta Neuropathol. NIH Please enable it to take advantage of the complete set of features! 2010 Mar;18(3):124-31. doi: 10.1016/j.tim.2009.12.003. Transcriptome analysis of the Capra hircus ovary. eCollection 2016. USA.gov. However, in Europe serotype 9 strains also contribute substantially to S. suis-associated invasive diseases of piglets. Silva LM, Baums CG, Rehm T, Wisselink HJ, Goethe R, Valentin-Weigand P. Vet Microbiol. J. Pohlenz. This site needs JavaScript to work properly. (2)2 Tieraerztliche Gemeinschaftspraxis Dres. (2)Institut für Pathologie, Stiftung Tierärztliche Hochschule Hannover. Toward Understanding the Genetic Basis of Yak Ovary Reproduction: A Characterization and Comparative Analyses of Estrus Ovary Transcriptiome in Yak and Cattle. Bibliografische Informationen der Deutschen Bibliothek Die Deutsche Bibliothek verzeichnet diese Publikation in der Deutschen Nationalbibliografie; Detaillierte bibliografische Da 2020 Jul 25;21(15):5289. doi: 10.3390/ijms21155289. Would you like email updates of new search results? (1)Institut für Pathologie, Stiftung Tierärztliche Hochschule Hannover, Hannover, Germany. Institut für Pathologie, Tierärztliche Hochschule, Bunteweg 17, D‐30559 Hannover, Germany. NLM The objective of this study was to determine the virulence of an MRP* SLY+ serotype 9 S. suis strain in comparison to an MRP+ EF+ SLY+ serotype 2 strain. Institut für Pathologie, Tierärztliche Hochschule Hannover, Peter Wohlsein. Institut für Mikrobiologie und Tierseucben Direktor: Prof. Dr. W. Bisping der Tierärztlichen Hochschule Hannover Tierärztliche Hochschule, 3 Hannover, Bischofsholer Damm 15. Kock C, Beineke A, Seitz M, Ganter M, Waldmann KH, Valentin-Weigand P, Baums CG. TiHo Hannover - Institut für Pathologie Toxicologic Pathology Training Program A comprehensive Toxicologic Pathology Program is offered within the residency program of the TiHo. | Corresponding Author. Author information: (1)Klinik für Rinder, Stiftung Tierärztliche Hochschule Hannover. The University of Veterinary Medicine Hannover, Foundation (TiHo) is a nationally and internationally recognized institution of higher education known for its excellence in veterinary science and its interdisciplinary focus. (1)Institut für Pathologie, Tierärztliche Hochschule Hannover, 30559 Hannover, Germany. PMID: 12016561 DOI: 10.1055/s-2002-30116 Abstract The mode of action of probiotics is still incompletely understood. Epub 2009 Jun 21. Friederike Döring: Die intrazelluläre Lokalisation von Isoformen des Fibroblastenwachstumsfaktors – 2 (FGF-2). Microarray analysis reveals gene and microRNA signatures in diabetic kidney disease. HHS This page... Print this page. | Beineke A, Puff C, Seehusen F, Baumgärtner W. Vet Immunol Immunopathol. University Overview Founded in 1778, Tierärztliche Hochschule Hannover (University of Veterinary Medicine Hannover) is a non-profit public higher-education institution located in the urban setting of the large city of Hannover (population range of 500,000-1,000,000 inhabitants), Lower Saxony. andreas.beineke@tiho-hannover.de Harbor porpoises from the North and Baltic Seas exhibit a higher incidence of bacterial infections compared to whales from less polluted arctic waters. Acta Neuropathol. Epub 2003 Aug 15. New aspects of the pathogenesis of canine distemper leukoencephalitis. Clipboard, Search History, and several other advanced features are temporarily unavailable. NCI CPTC Antibody Characterization Program. However, histological screenings of these animals revealed pathological lesions, such as mild focal suppurative meningitis. Intranasal immunization with a live Streptococcus suis isogenic ofs mutant elicited suilysin-neutralization titers but failed to induce opsonizing antibodies and protection. 2009 Jan 15;127(1-2):1-18. doi: 10.1016/j.vetimm.2008.09.023. Trends Microbiol. Search Google Scholar for this author, R. Müller-Peddinghaus. Institute of Pathology, Section of Immunopathology and Institute of Virology, School of Veterinary Medicine, Hannover. The present review decribes the role of CD44 antigen (CD44), the principle cell surface receptor for hyaluronate and extracellular matrix (ECM) processing enzymes (matrix metalloproteinases [MMPs]) and their inhibitors (TIMPs) in the pathogenesis of demyelination. Centre National des Listeria, Institut de Microbiologie, CHUV, CH‐19 Sud 1011, Lausanne, Switzerland . Aerial photography: Department of Pathology. Due to the central nervous system (CNS) tropism of the virus and associated neuropathological changes, demyelinating canine distemper encephalitis (CDE) represents a relevant model for human demyelinating diseases like multiple sclerosis. The skin lesions were divided into four macroscopic groups: scaling (group I, n = 5), hyperkeratotic and hyperplastic plaque‐like lesions (group II, n = 14), nodular skin masses (group III, n = 16) and verrucous skin lesions (group IV, n = 2). Prevention and treatment information (HHS). vet. 2019 Oct 10;3:100046. doi: 10.1016/j.jvacx.2019.100046. (3)3 Institut für Pathologie der Stiftung Tieraerztliche Hochschule Hannover, Hannover, Germany. Ligation of CD44 in the early phase may induce chemokines and cytokines and hence initiate and perpetuate the inflammatory process. Center for Systems Neuroscience, Stiftung Tierärztliche Hochschule Hannover, Medizinische Hochschule Hannover, ... Bedeutung für die molekulare Pathologie der Spinalen Muskelatrophie. in northwestern Madagasca. Office: Phone: 0049-(0)511- 953-8621; 0049-(0)511-953-8664 Fax: 0049-(0)511-953-8675 Diagnostic service section - consultation hours: Monday – Friday from 2.30 pm – 4.30 pm; phone: 0049-(0)511-953-8622 Aerial photography: Department of Pathology. Would you like email updates of new search results? Institut für Pathologie, Tierärztliche Hochschule Hannover, Bünteweg 17, D‐3000 Hannover 71, Germany . doi: 10.1371/journal.pone.0121586. Institute of Microbiology and Infectious Diseases of Animals, School of Veterinary Medicine, Hannover, Germany. Doctoral student . Dr. med. Epub 2018 May 21. Stiftung Tierärztliche Hochschule Hannover. Stiftung Tierärztliche Hochschule Hannover. Experimental intranasal and intravenous infections of 7-8 weeks old SPF piglets were investigated with regard to clinic and pathology. 1 Klinik für kleine Klauentiere, forensische Medizin und Ambulatorische Klinik, Stiftung Tierärztliche Hochschule Hannover › Author Affiliations. 6 Kliniken, 19 Institute, 3 Fachgebiete und 3 Außenstellen gehören zur Stiftung Tierärztliche Hochschule Hannover. Stiftung Tierärztliche Hochschule Hannover. Institut für Pathologie der Tierärztlichen Hochschule Hannover, Bünteweg 17, D‐3000 Hannover 71, Germany. Interestingly, expression of MRP within meningitis lesions was demonstrated for both pathotypes via immunohistochemistry. … Institut für Pathologie, Tierärztliche Hochschule Hannover, Bischofsholer Damm 15, D‐3000 Hannover 1Search for more papers by this author. doi: 10.1371/journal.pone.0152675. Lempp C, Spitzbarth I, Puff C, Cana A, Kegler K, Techangamsuwan S, Baumgärtner W, Seehusen F. Viruses. COVID-19 is an emerging, rapidly evolving situation. 2020 May 6;6:12. doi: 10.1186/s40813-020-00150-6. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Epub 2006 Jan 20. Please enable it to take advantage of the complete set of features! In acute and subacute CDE, a plaque-associated CD44 up-regulation is found that parallels astrocyte activation. Save as PDF. Arwid Daugschies Institut für Parasitologie Veterinärmedizinische Fakultät der Universität Leipzig 2. Shen M, Di G, Li M, Fu J, Dai Q, Miao X, Huang M, You W, Ke C. Sci Rep. 2018 Apr 19;8(1):6269. doi: 10.1038/s41598-018-24645-z. Epub 2010 Jan 12. Publication History. Thus, intravenous application of this serotype 9 strain is required to evaluate heterologous protection in the course of vaccine development based on serotype 2 strains in the future. Clonal expansion of a virulent Streptococcus suis serotype 9 lineage distinguishable from carriage subpopulations. It is often referred to as TiHo by its staff and students. Andrea Düngelhoef, Sophie Gschaider, Jana Seele, Nadine Büttner, and Christoph Hirche are acknowledged for their excellent work during their practicals. Willemse N, van der Ark KCH, Stockhofe-Zurwieden N, Smith H, Picavet DI, van Solt-Smits C, Wisselink HJ, Schultsz C, de Greeff A. Sci Rep. 2019 Oct 28;9(1):15429. doi: 10.1038/s41598-019-51576-0. PLoS One. Dr. med. 2000 Feb;99(2):138-46. doi: 10.1007/pl00007417. | Clipboard, Search History, and several other advanced features are temporarily unavailable. Zhao ZQ, Wang LJ, Sun XW, Zhang JJ, Zhao YJ, Na RS, Zhang JH. 2009 Nov 18;139(3-4):310-7. doi: 10.1016/j.vetmic.2009.06.024. Miao Q, Baumgärtner W, Failing K, Alldinger S. Acta Neuropathol. Mol Med Rep. 2018 Feb;17(2):2161-2168. doi: 10.3892/mmr.2017.8177. Project: Effects of habitat fragmentation on parasite communities in mouse lemurs (Microcebus spp.) The working group „Behavioural ecology and conservation genetics“ aims to understand the factors, that drive and influence the evolution of social structures, the demographic composition, ecological niche construction, distribution, connectivity and the survival of populations. Abstract; Full Text; References Buy Article Permissions and Reprints. Search for more papers by this author. 2019 Nov 20;8(4):249. doi: 10.3390/pathogens8040249. 2014 Jul 2;6(7):2571-601. doi: 10.3390/v6072571. eCollection 2020. Bacteriological culture and immunohistochemistry of the brain confirmed association with the S. suis challenge strains in all cases with clinical manifestations. A 5-year-old German-Holstein cow was presented with a swelling of the head which had been present for 3 months. Rieckmann K, Seydel A, Klose K, Alber G, Baums CG, Schütze N. Vaccine X. Virulence-associated gene profiling of Streptococcus suis isolates by PCR. Zusammenfassung. Up-regulation of the hyaluronate receptor CD44 in canine distemper demyelinated plaques. (4)4 Klinik für Heimtiere, Reptilien, Zier- und Wildvoegel, Stiftung Tieraerztliche Hochschule, Hannover… Gutachter: Univ.-Prof. Marion Hewicker-Trautwein und PD Dr. med. Institut für Pathologie, Tierärztliche Hochschule Hannover, FRG. Medizinische Hochschule Hannover, 2006. Tierärztliche Hochschule Hannover Prof. Dr. med. Search for more papers by this author. In conclusion, this study demonstrates that MRP* SLY+ serotype 9 strains are less virulent for growers than MRP+ EF+ SLY+ serotype 2 strains. Institut für Pathologie, Tierärztliche Hochschule Hannover › Author Affiliations › Further Information. Donhauser & Schöneberger, Bingen am Rhein, Germany. PLoS One. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. J. Pathogenesis and immunopathology of systemic and nervous canine distemper. Fragen der Diagnostik: Geschäftszimmer, Tel.-Nr. Epub 2009 May 18. 2015 Mar 30;10(3):e0121586. Proteomics Studies on the three Larval Stages of Development and Metamorphosis of Babylonia areolata. Tierärztliche Hochschule Hannover Population and molecular genetic analyses of persistent right aortic arch and primary cataracts in the German Pinscher INAUGURAL-DISSERTATION zur Erlangung des Grades einer Doktorin der Veterinärmedizin - Doctor medicinae veterinariae – (Dr. med. vorgelegt von Julia Menzel Stuttgart Hannover 2010 . Fittipaldi N, Fuller TE, Teel JF, Wilson TL, Wolfram TJ, Lowery DE, Gottschalk M. Vet Microbiol. Streptococcus (S.) suis is an invasive porcine pathogen causing meningitis, septicemia, arthritis and other diseases. The program is subdivided into different seminars (modules) and receives support from speakers from Pharmaceutical and Chemical companies mainly located in Germany. Abteilung für Experimentelle Pathologie, Dr. Karl Thomae GmbH, Biberach/Riß, und Institut für Pathologie, Abteilung für Immunpathologie, Tierärztliche Hochschule Hannover, Hannover, BRD See all articles by this author. Universität Hannover, 2007. | In summary, CD44 and MMPs might be associated with the onset of demyelination and may interact to initiate ECM disturbances. In the chronic phase, it is conceivable that a MMP-TIMP imbalance may be the motor for lesion progression with a simultaneous influx of CD44-positive activated immune cells. | "Perfect place to start a veterinary career" 2016 Jul;11:941-54. doi: 10.2217/fmb-2016-0028. Epub 2008 Oct 4. | Tenenbaum T, Asmat TM, Seitz M, Schroten H, Schwerk C. Future Microbiol. Meurer M, Öhlmann S, Bonilla MC, Valentin-Weigand P, Beineke A, Hennig-Pauka I, Schwerk C, Schroten H, Baums CG, Köckritz-Blickwede MV, de Buhr N. Int J Mol Sci. Gregor Warnecke Institut für Herz-, Thorax-, Transplantations- und Gefäßchirurgie Medizinische Hochschule Hannover 1. Carlos Hermosilla Institut für Parasitologie 2 Institut für Pathologie, Stiftung Tierärztliche Hochschule Hannover, M. Ganter. Epub 2005 Aug 25. Serotype distribution and production of muramidase-released protein, extracellular factor and suilysin by field strains of Streptococcus suis isolated in the United States. Rieckmann K, Pendzialek SM, Vahlenkamp T, Baums CG. See 3 photos and 3 tips from 80 visitors to Tierärztliche Hochschule Hannover. Up-regulation of mRNA for matrix metalloproteinases-9 and -14 in advanced lesions of demyelinating canine distemper leukoencephalitis. (1)Institut für Pathologie, Stiftung Tierärztliche Hochschule Hannover, D-30173 Hannover, Germany. Stiftung Tierärztliche Hochschule Hannover. In chronic lesions, CD44 expression declines together with the number of glial fibrillary acidic protein (GFAP) positive astrocytes. This site needs JavaScript to work properly. R. Müller-Peddinghaus . Role of Bacterial and Host DNases on Host-Pathogen Interaction during, A critical review speculating on the protective efficacies of autogenous, From Stable to Lab-Investigating Key Factors for Sudden Deaths Caused by, Vaccination with the immunoglobulin M-degrading enzyme of. Research topics. Corresponding Author . To study the interactions between probiotic micro-organisms and the host their effects on morphology and mucins of the intestinal mucosa were investigated. Vet Immunol Immunopathol. Comparative mRNA and miRNA expression in European mouflon (Ovis musimon) and sheep (Ovis aries) provides novel insights into the genetic mechanisms for female reproductive success. Gregor Warnecke 2. In this phase, a decrease of MMP and TIMP expressions apart from MMP-11, -12, and -13 is obvious. In contrast to the virulent serotype 2 strain, the serotype 9 strain did not cause disease with clinical manifestations after intranasal administration. vet. vet.) Beyerbach (Stiftung Tierärztliche Hochschule Hannover, Hannover, Germany) kindly provided support in statistical analysis. 2009 Dec 15;132(2-4):135-45. doi: 10.1016/j.vetimm.2009.05.009. We are a leader in research, teaching and services in veterinary medicine and train young scientists in all areas of veterinary science. Hennig-Pauka I, Imker R, Mayer L, Brügmann M, Werckenthin C, Weber H, Menrath A, de Buhr N. Pathogens. 2016 Apr 4;11(4):e0152675. NIH Further Information. The principal histological findings were hyperkeratosis and epidermal hyperplasia. Hannover und Umgebung, Deutschland Scientific Assistant at the Institute for Experimental Pathology of the Medical School Hannover (Director: Professor Dr. U. Mohr). Studies on pathogenesis as well as vaccine trials have focused on serotype 2 strains, which are worldwide the most prevalent among invasive isolates. Gutachten: Prof. Dr. med. Corresponding Author. The University of Veterinary Medicine Hanover (German: Tierärztliche Hochschule Hannover, TiHo) is a university in Hanover and one of the five facilities for veterinary medicine in Germany, and the only one that remains independent. COVID-19 is an emerging, rapidly evolving situation. 1 Institut für Pathologie, Tierärztliche Hochschule Hannover, Germany. HHS Ziel dieser Arbeit war es, festzustellen, ob und wann eine PCV 2-Infektion vor 1998, dem Jahr des erstmaligen Nachweises von PCV 2 in Deutschland, im Sektionsmaterial des Instituts für Pathologie der Stiftung Tierärztliche Hochschule Hannover aufgetreten ist. Prevention and treatment information (HHS). D-30559 Hannover, Germany e-mail: Send e-mail . NLM vet. Clinical examination revealed a 15 × 20 × 15 cm firm … Porcine Health Manag. 2006 Jun 15;115(1-3):117-27. doi: 10.1016/j.vetmic.2005.12.013. Institut für Pathologie Tierärztliche Hochschule Hannover PD Dr. med. 2003 Nov;106(5):486-94. doi: 10.1007/s00401-003-0754-6. Epub 2016 Jun 30. Andreas Beineke Institut für Pathologie Tierärztliche Hochschule Hannover Prof. Dr. med. : 0511 / 953-8621 , 0511 / 953-8664 Diagnostik-Sprechstunden: Mo. Uncovering newly emerging variants of Streptococcus suis, an important zoonotic agent. A. Navarro Camarro. Yang J, Li X, Cao YH, Pokharel K, Hu XJ, Chen ZH, Xu SS, Peippo J, Honkatukia M, Kantanen J, Li MH. In addition, in this plaque type, CD44 is expressed on the cell membrane of perivascular mononuclear cells. 2019 Feb;122(2):172-186. doi: 10.1038/s41437-018-0090-1. (3)Zentrum für Systemische Neurowissenschaften Hannover, ZSN. Likewise, MMPs and TIMPs are prominently up-regulated in these lesions and are expressed mostly by astrocytes and microglia.
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