Adenuric is used to treat long-term hyperuricaemia (high levels of uric acid or ?urate? %PDF-1.5 %���� It contains information that is important to you. When this happens in the joints and causes pain, it is known as ?gout?. Bij sommige mensen hoopt de hoeveelheid This is a summary of the European public assessment report (EPAR) for Adenuric. Change to, or new use for medicine ; ... Febuxostat 80 mg can be used in patients concomitantly treated with theophylline without risk of increasing theophylline plasma levels. The main measure of effectiveness was based on their blood uric acid levels. What is Adenuric used for? Adenuric is indicated for the treatment of chronic hyperuricaemia in conditions where urate deposition has already occurred (including a history, or presence of, tophus and/or gouty arthritis). Keeping uric acid levels low by taking Adenuric® once every day stops crystals building up, and over time it reduces symptoms. Adenuric Tablet may also be used for purposes not listed in this medication guide. The CHMP concluded that Adenuric was more effective than allopurinol at lowering blood uric acid levels including in patients undergoing chemotherapy , but that it could carry a greater risk of side effects affecting the heart and blood vessels. Quality of the evidence. Similar results were seen in the second study after a year. Azathioprine (Aza-thy-o-preen) — used to treat immune conditions, such as rheumatoid arthritis. The European Commission granted a marketing authorisation valid throughout the European Union for Adenuric on 21 April 2008. Blood uric acid levels were measured every month. Attacks of gout can still occur during the first few months of treatment, so it is recommended that patients take other medicines to prevent attacks of gout for at least the first six months of treatment with Adenuric. For the prevention and treatment of hyperuricaemia in patients undergoing chemotherapy, the recommended dose is 120 mg once a day. in the blood). Adenuric Tablet is used for High blood uric acid, Painful joint conditions and other conditions. When this happens in the joints and causes pain, it is known as ‘gout’. By reducing the production of uric acid, Adenuric can reduce levels of uric acid in the blood and keep them low, stopping crystals from building up. The study lasted six months. h��W�n�8�>&Y^D��i lڢ�6yPm5֑ Y���3CɖSi��X 'C���p�pHk��F��+�-raD � �� It is these crystals that cause the characteristic pain and inflammation of gout.Uric acid is produced by an enzyme in the body called xanthine oxidase. In patients who are on chemotherapy a reduction in uric acid levels is expected to reduce the risk of tumour lysis syndrome. Reasons for updating. It is generally recommended only for people who cannot take allopurinol. Adenuric 120 mg film-coated tablet updates: 4.1 Therapeutic indications. Febuxostat, sold under the brand names Uloric and Adenuric among others, is a medication used long-term to treat gout due to high uric acid levels. Adenuric was more effective than allopurinol and placebo in treating hyperuricaemia by reducing blood uric acid levels. Menarini International Operations Luxembourg S.A. (MIOL). Adenuric is used to treat adults with long-term hyperuricaemia (high levels of uric acid or ‘urate’ in the blood). Contents hide 1 Read all of this leaflet carefully before you start taking this medicine. For selected RADAR reviews, NPS MedicineWise summarises the evidence used in developing our conclusions about a new medicine's efficacy and safety using the GRADE criteria for assessing quality of the evidence. Discuss the Adenuric Consumer Medicine Information (CMI) leaflet with the patient. ADENURIC tabletten bevatten de werkzame stof febuxostat en worden gebruikt voor de behandeling van jicht, een ziekte die in verband wordt gebracht met een teveel aan een chemische stof in het lichaam die urinezuur (uraat) wordt genoemd. ADENURIC tabletten bevatten de werkzame stof febuxostat en worden gebruikt voor de behandeling van jicht, een ziekte die in verband wordt gebracht met een teveel aan een chemische stof in het lichaam die urinezuur (uraat) wordt genoemd. Febuxostat is used to treat gout. 0 Rare serious hypersensitivity (allergic) reactions to Adenuric have occurred post-marketing. Adenuric should be started two days before chemotherapy and continued for at least 7 days. Febuxostat is used to keep uric acid levels from getting to high in people with gout. In patients with blood cancer who were undergoing chemotherapy, Adenuric was as effective as allopurinol in controlling blood levels of uric acid: in 98.3 % of patients (170 out of 173) on Adenuric blood levels of uric acid normalised compared with 96 % (166 out of 173) of patients on allopurinol. HERE are many translated example sentences containing "WURDE ADENURIC" - german-english translations and … You are therefore advised to be selective about which sections or pages you wish to print. is also used to treat and prev ent high levels of uric acid in the blood in adults with blood It works by blocking an enzyme called xanthine oxidase, which is needed to make uric acid in the body. ((�ct�����"lف�0��E���`�`�crd�b�c�bZ�����A�3�3��1�.��U@[g2�@�j�W��� [8��>�0�:Hq30J�C� If� h�bbd``b`�$��X��?�`., �#�0� �e ���MHpE �h��- !�$�$��X߁��?&F^ ����r�?c�'� M)J Change to separate SmPC for Adenuric 80 mg film-coated tablets Updated on 7 May 2015 PIL . A risk management plan has been developed to ensure that Adenuric is used as safely as possible. h�b```�~V�>``��0pt0�����! endstream endobj 127 0 obj <>/Metadata 9 0 R/Outlines 18 0 R/PageLayout/OneColumn/Pages 124 0 R/StructTreeRoot 39 0 R/Type/Catalog>> endobj 128 0 obj <>/ExtGState<>/Font<>/XObject<>>>/Rotate 0/StructParents 0/Tabs/S/Type/Page>> endobj 129 0 obj <>stream The main measure of effectiveness was the number of patients whose final three blood uric acid levels were below 6 mg/dl. This can reduce the symptoms of gout. Adenuric treatment should not be stopped if an attack of gout occurs. How do I take Adenuric? %%EOF Febuxostat is for use only in people who cannot take another medicine called … Translations in context of "WURDE ADENURIC" in german-english. 147 0 obj <>/Filter/FlateDecode/ID[<2D311DD9BFB61E49AAFE3862AA76FFB1>]/Index[126 38]/Info 125 0 R/Length 100/Prev 73212/Root 127 0 R/Size 164/Type/XRef/W[1 2 1]>>stream Based on this plan, safety information has been included in the summary of product characteristics and the package leaflet for Adenuric, including the appropriate precautions to be followed by healthcare professionals and patients. When this happens in the joints and causes pain, it is known as ‘gout’. What ADENURIC is used for. Febuxostat is used to keep uric acid levels from getting to high in people with gout. For more information about treatment with Adenuric, read the package leaflet (also part of the EPAR) or contact your doctor or pharmacist. Adenuric is used to treat adults with long-term hyperuricaemia (high levels of uric acid or ‘urate’ in the blood). When this happens in the joints and causes pain, it is known as Ngout'. ADENURIC 120 mg tablets is also used to treat and prevent high blood levels of uric acid that may occur when you start to receive chemotherapy for blood cancers. In some people, the amount of uric acid builds up in the blood and may become too high to remain soluble. ADENURIC is used in the treatment of long-standing high uric acid levels in the blood. 2 1. Febuxostat is used to treat gout. Adenuric . High levels of uric acid in the blood lead to development of crystals which deposit in the joints causing pain, swelling and tenderness. Gout is caused by too much uric acid in the blood that leads to a build-up of uric acid crystals in the joints. Adenuric is used in patients who already have signs of a build -up of crystals, including gouty arthritis (pain and inflammation in the joints) or tophi (‘stones’, larger deposits of urate crystals that can cause joint and bone damage). Adenuric is used in patients who already have signs of a build-up of crystals, including gouty arthritis (pain and inflammation in the joints) or tophi (‘stones’, larger deposits of urate crystals that can cause joint and bone damage). ADENURIC 120 mg tablets are also used to treat and prevent high blood levels of uric acid that may occur when you start to receive chemotherapy for blood cancers. 17, 18. This medicine is not addictive. Treated.com: snel, eenvoudig, geen vereiste registratie én gratis verzending. It is taken by mouth. Adenuric is used to treat long-term hyperuricaemia (high levels of uric acid or ‘urate’ in the blood). It explains how the Committee for Medicinal Products for Human Use (CHMP) assessed the medicine to reach its opinion in favour of granting a marketing authorisation and its recommendations on the conditions of use for Adenuric. In the first study, 48% of the patients taking 80 mg Adenuric once a day (126 out of 262) and 65% of the patients taking 120 mg once a day (175 out of 269) had levels of uric acid below 6 mg/dl in the final three measurements. ADENURIC is used to prevent gout, but is not used to treat acute attacks of gout (also called flares). Your doctor may have prescribed it for another reason. When initially started, medications such as NSAIDs are often recommended to prevent gout flares. Reducing high blood uric acid levels (hyperuricaemia) in gout and thus preventing gout attacks. 1. The most commonly reported side effects with Adenuric are gout flare-ups, abnormal liver test results, diarrhoea, nausea (feeling sick), headache, rash and oedema (swelling). Adenuric is a substance used for the treatment of gout, to reduce the production of uric acid in the body. When this happens, urate crystals may form in and around the joints and kidneys. ADENURIC works sufficiently quickly to allow retesting of the serum uric acid after 2 weeks. This was compared with 22% of the patients taking allopurinol (60 out of 268) and none of the 134 patients taking placebo. Please note that the size of the above document can exceed 50 pages. Blijf doorgaan met het elke dag innemen van ADENURIC, zelfs wanneer u geen jichtaanval ervaart. ADENURIC tablets contain the active substance febuxostat and are used to treat gout, which is associated with an excess of a chemical called uric acid (urate) in the body. The active substance in Adenuric, febuxostat, reduces the formation of uric acid. High levels of uric acid in the blood lead to development of crystals which deposit in the joints, causing pain, swelling and tenderness, known as a condition called gout. When chemotherapy is given, cancer cells are destroyed, and uric acid levels increase in the blood Mercaptopurine (mer-kap-toh-pyoo-reen) — used to treat cancer and immune conditions. �吹��A:�)y�4i�3�ʣ�d�)atE��ha���Xc.���y�-�XYa�Ϸî,~���zY>�O��#�y��9��ķb�-�����n������Cɏ����������h��Rή��?�Z���ySʷO��Y[��\���$���?6˲�껓鲬۪}>��˻j�6�'���ky*g��ͪ|��P�3�.�C+o�ؼ/���Vx��E���2���Uq�V^����|�4?�Pѐ�^yֿ����Z=�|)�eQ���Z��0 ��P|��.E���M�i���Hno�2ESלL/f�[�����%����wӋ�b#�Hʋ�N�ü#���ז܀.� ���1y3ό�;eooG�9����q�R����ؖ�L����%�s���neZL���_u�I%��v�s�0ݹ~=ݙ�����tZ`���f����$6�W���>D7U=������j���hđ$��������^��Y-���� ~�Jd���y5�e�Ω�t�",�hB��w/��g��!=���001�{ ���� ��[�@����:��uߣ�;Ѝe̓ �O�"$�uβw�wd��M'���P��0����ѧ~���s ���>E��h.o��:ﲼZ� �O���}���c!9�������S�z�)�hD��#1�hRhz���2�Vm�=��Y�m�YHku����� �`aڍ=�H2��̉�+'^�\�6�`^(��ā#�y#NA�i���p>��e ^$���_�iK�/\��������S��*��a�qՁ�Zm=8���h�&dx�ڠX:9���"���i/"Ψ�����Aq̨(��`U�53T��yW����p��� 3� }M�TІ]�M��ϨJ�͐�$����)��I:�b�ᶇ�%��j�}x�q���)� �������@?bZp�a�(�. If serum uric acid is > 6 mg/dL (357 µmol/L) after 2-4 weeks, ADENURIC 120 mg once daily may be considered. Didanosine (dy-da-no-seen) — sometimes used in the treatment of HIV. Adenuric tablets contain the active ingredient febuxostat, which is a type of medicine called a xanthine oxidase inhibitor. Treatment of chronic hyperuricaemia in conditions where urate deposition has already occurred (including a history, or presence of, tophus and/or gouty arthritis). What you need to know before using ADENURIC 4 Do not use ADENURIC 5 Warnings and cautions 6 Children […] This is known as a condition called gout. European Medicines AgencyDomenico Scarlattilaan 61083 HS AmsterdamThe Netherlands. Adenuric is also used to treat and prevent high levels of uric acid in the blood in adults with blood cancers who are on chemotherapy and at risk of tumour lysis syndrome (a complication due to the breakdown of cancer cells causing a sudden rise of uric acid in the blood which can cause damage to the kidneys). Hyperuricaemia can lead to urate crystals forming and building up in the joints and the kidneys. For the prevention and treatment of hyperuricaemia in patients undergoing chemotherapy, Adenuric has been studied in one main study involving 346 adult patients undergoing chemotherapy for blood cancer. The therapeutic target is to decrease and maintain serum uric acid below 6 mg/dL (357 μmol/L). endstream endobj startxref What is it and how is it used? Febuxostat is used to treat gout. Keeping uric acid levels low for long enough can also shrink tophi. For the treatment of long-term hyperuricaemia, the recommended dose of Adenuric is 80 mg once a day.
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